Thursday 10 September 2009

A good historical comparison of Spanish Flu

A good summary of written documents but are not clear of theories vs
facts.

There is no proof that Spanish flu mutated. It was only assumed.
the fatality rate for Spanish flu was only 0.67% overall, as recorded
in Wales and collected by a doctor there.

Even the data in New York, recorded a case fatality rate of 1.4% peak
in winter. Current Swine Flu recorded even higher rates in some
places.

So I suspect the fatality rate is similar to common flu except that
Spanish and Swine flu affects all age groups, therefore it is more
infectious because it has more carriers.

It also kills more people. As more people require intensive care,
hospitals cannot cope, raising the normal fatality rate of 0.1% to
more than 1%.

This time round, we have Tamilflu to treat swine flu but fatality
rates are still high. Imagine how it would affect populations as they
run out of Tamiflu. Many authorities are delaying the issuing of
Tamilflu to days after the allowed usage date of 2 days after the
onset of symptoms.

This is not simply a recommended date, but compulsory date. Tamilflu
manufacturer, Roche, does not allow its usage to treat flu after 48
hours.


The Mother of All Viruses?
Is Another 1918 Pandemic Possible?

September 09, 2009

virus_outbreak_bw-apha-090907.jpg

Undated photograph: The emergency hospital at Camp Funston, Kansas,
during the 1918 influenza epidemic.
Source: Courtesy Armed Forces Institute of Pathology/Contra Costa
Times/KRT

A working-class father and his young family stand outside a clinic,
masks over their faces. While his wife and children wait anxiously,
worry creases his forehead. A mysterious virus has engulfed the
country and he is concerned about its effects. What will happen to my
family if I'm unable to work? he wonders.

Short-staffed hospitals overwhelmed with patients attempt to
quarantine the infected before others contract the illness. But it is
so contagious that even nurses fall prey.

Frustrated about the unexplained sickness, authorities shut down
schools and force businesses to close, bringing the whole nation to a
halt. Transportation systems all but stop, and health officials urge
citizens not to leave their homes.

As the tired father waits in line, he recalls news reports about the
illness ballooning into a pandemic-level outbreak. Glancing at his
family, he wonders, Will we be next?

Although this description is eerily reminiscent of what is occurring
today with the H1N1 virus, the year is 1918. And the influenza
pandemic depicted above is not the current H1N1 swine flu outbreak,
but the Spanish influenza that took the lives of 40 to 100 million
people worldwide from 1918 to 1919.
Unparalleled in History

The early 20th-century pandemic started much the same as the current
one. Three years before the 1918 virus took its worst toll, it first
surfaced in birds, according to the Centers for Disease Control and
Prevention.

"Recently published sequence and phylogenetic analyses suggest that
the genes encoding the HA and neuraminidase (NA) surface proteins of
the 1918 virus were derived from an avianlike influenza virus shortly
before the start of the pandemic and that the precursor virus had not
circulated widely in humans or swine in the few decades before…
Regression analyses of human and swine influenza sequences obtained
from 1930 to the present place the initial circulation of the 1918
precursor virus in humans at approximately 1915–1918."

From 1915 to 1916, the United States suffered a hard-hit respiratory
disease epidemic, upping the death toll resulting from pneumonia and
influenza complications. Although mortality rates decreased by 1917,
people's weakened immune systems paved the way for the pandemic's
first wave in March 1918.

Spanish influenza initially appeared in Kansas in early spring, but
was first recorded as extremely virulent in several soldiers in
Boston, Mass., who had returned from fighting overseas in the First
World War. The bustling port city became a breeding ground for the
virus. Within three days, it infected 58 military personnel. The sick
were sent to Chelsea Naval Hospital. From there, influenza infected
civilians, with cases multiplying rapidly across the state and
country.

The pandemic continued in three stages over a 12-month period: The
first wave reached Europe, the U.S. and Asia in late spring and
summer; a second—and more deadly—strain spread approximately six
months later, wiping out entire families from September to November
1918; and a third wave struck in early spring of 1919.
"Most Viscous Type"

Unlike most viruses, which normally affect the very young, the weak
and the elderly, the 1918 influenza targeted healthy adults from the
ages of 20 to 40. Victims suffocated as their immune systems backfired—
overreacted—filling their lungs with a reddish liquid, which often
bubbled out of them as they died.
Expand Image

Global pandemic: People around the world wear face masks to protect
themselves against the risk of contracting swine flu, officially known
as influenza A (H1N1).
Source: AFP/Getty Images

A letter written by a military doctor on Sept. 29, 1918, described the
dreadful conditions at Fort Devens, near Boston.

"These men start with what appears to be an attack of la grippe or
influenza, and when brought to the hospital they very rapidly develop
the most viscous type of pneumonia that has ever been seen. Two hours
after admission they have the mahogany spots over the cheek bones, and
a few hours later you can begin to see the cyanosis extending from
their ears and spreading all over the face, until it is hard to
distinguish the coloured men from the white. It is only a matter of a
few hours then until death comes, and it is simply a struggle for air
until they suffocate."

Later he wrote, "It takes special trains to carry away the dead. For
several days there were no coffins and the bodies piled up something
fierce, we used to go down to the morgue...and look at the boys laid
out in long rows. It beats any sight they ever had in France after a
battle. An extra long barracks has been vacated for the use of the
morgue, and it would make any man sit up and take notice to walk down
the long lines of dead soldiers all dressed up and laid out in double
rows" (PBS).

One pandemic survivor recounted the bodies that stacked up in
Vancouver, Canada: "The undertaking parlours couldn't handle the
bodies as people died...they were having to use school auditoriums and
places like that to store bodies temporarily" (The Canadian Press).

A survivor stated that in Washington, D.C., "the flu's spread and the
ensuing restrictions 'made everybody afraid to go see anybody,' he
said. 'It changed a lot of society…We became more
individualistic'" (MSNBC).
Social Distancing

An effective measure at the time was social distancing—a method
(related to the quarantine laws of the Bible) that public health
officials in the 21st century still consider one of the most powerful
ways to stop illness without a vaccine.

In St. Louis, Missouri, officials instantly closed schools, cancelled
church services, and banned gatherings of more than 20 people,
including funerals, weddings, dances and sports activities. As a
result, the city's death rate was only one-eighth that of Philadelphia—
one of the cities hardest hit by influenza, which health authorities
maintain took action too late.

St. Louis, however, did make one fatal mistake.

"On Nov. 14, 1918—in high spirits three days after the armistice that
ended the war, and with influenza cases declining—the city reopened
schools and businesses. Two weeks later, the second wave of the
epidemic struck, this time with children making up 30 percent to 40
percent of the infections" (The New York Times).

Since the first wave of the pandemic did not hit as hard—merely
infecting thousands, but not killing them—people did not take it
seriously until it was too late. By the time influenza ran its full
course, a fifth of the world population contracted the flu—killing as
many as 100 million.

Throughout America, churches shut down, government banned public
meetings, schools closed, businesses collapsed from lack of customers,
state institutions became overrun with orphaned children, infected
postal carriers were unable to deliver mail, and rancid garbage lined
city streets. Decomposing bodies overflowed from morgues and had to be
stored in nearby elementary schools. Wherever people ventured, the
smell of rotting flesh haunted them.

In the book Flu: The Story of the Great Influenza Pandemic of 1918 and
the Search for the Virus That Caused It, Gina Kolata, commentator for
The New York Times, stated that if the Spanish Influenza were to
strike the U.S. now, it would have devastating results. "If such a
plague came today, killing a similar fraction of the U.S. population,
1.5 million Americans would die, which is more than the number felled
in a single year by heart disease, cancers, strokes, chronic pulmonary
disease, AIDS, and Alzheimer's disease combined."

This is not to mention that millions—perhaps even as many as 1.8
billion, according to current population estimates—would die
worldwide.

One of the strangest parts of the virus, Ms. Kolata noted, is that
scientists still have not been able to determine what made it so
deadly.

"No one knows for sure where the 1918 flu came from or how it turned
into such a killer strain," she wrote. "All that is known is that it
began as an ordinary flu but then it changed. It infected people in
the spring of 1918, sickening its victims for about three days with
chills and fever, but rarely killing them. Then it disappeared,
returning in the fall with the power of a juggernaut."
Snapshot of Today

As of this writing, the latest version of the swine flu has not
attacked as vehemently as did later strains of the 1918 influenza. The
World Health Organization (WHO) estimates there are 182,166 suspected
cases of H1N1 worldwide. However, unlike the Spanish flu, those who
contract the H1N1 virus today are more likely to live than die—the WHO
reports that only 1,799 people have fatally succumbed.

Nonetheless, the illness continues to spread. The most updated
information from the WHO revealed newly detected, first-time cases in
Ghana, Zambia and Tuvalu (the fourth smallest nation on Earth).

A map of the infected areas shows that even though almost all
countries have reported only 10-50 virus-related deaths, cases have
stricken all corners of the world. So far, the only places H1N1 has
not claimed lives are Greenland, Mongolia and parts of Western Africa.

But the death toll continues to accelerate.

Last month, swine flu cases in Britain doubled to 100,000 in one week
in July alone! The virus has had such a significant impact on the
country that within minutes of opening, the National Pandemic Flu
service website—capable of handling 1 million calls per week—crashed.

"Dr Alan Hay, director of the WHO's London-based World Influenza
Centre, said the extensive summer outbreak in Britain had not followed
expected patterns and warned that the health department needed to be
prepared for a more deadly form of the disease.

"'We have been a little surprised by the degree of spread of this
virus. A few weeks ago we anticipated that this was going to be a
short series of outbreaks that would probably peter out before
reappearing in the autumn or winter and that has proved not to be the
case,' he said" (Guardian).

Kuala Lumpur, Malaysia, recorded 569 new H1N1 infections in one day in
August—the highest number ever reported in such a short time period.
Around the same time, the Chinese Ministry of Health registered 132
new cases of H1N1 in two days, bringing the number of cases there to
2,861.

Even Martha's Vineyard, a small island off the coast of Massachusetts
known as a playground for the rich, was affected. A 26-year-old
Brazilian man died after being diagnosed with H1N1. He is among 447
people in the U.S. since April 2009 whose deaths have been linked to
the virus.

A startling report revealed, "Swine flu may infect half the U.S.
population this year, hospitalize 1.8 million patients and lead to as
many as 90,000 deaths, more than twice the number killed in a typical
seasonal flu, White House advisers said" (Star-Telegram).

The U.S. military also reported another 67 confirmed cases of swine
flu among soldiers in Iraq. Authorities suspect there could be dozens
more.
Just the Beginning

Although the virus initially jumped from one country to another,
sparking worldwide panic, deaths have been few and far between
compared to other pandemics. But researchers who have studied the
virus in the past, and the parallels of the 1918 strain to that of
today, say it may only be in its initial stages.

"The Spanish and swine flu viruses are very similar although the
current one does not seem to be as nasty—but it is in its early days
yet," John Powell, an associate clinical professor of public health at
Warwick University in the United Kingdom, said in an interview with
the British Daily Mail.

"There are enormous parallels with 1918 and our current pandemic," he
added. "They are spreading at a similar rate, but we don't know if the
virus will mutate…If it does, this is when it could become very
dangerous. But we are working on vaccines and we hope that they will
be sufficient" (ibid.).

The U.S. Health and Human Services originally ordered 120 million
doses of the inoculation to use before the approaching flu season, but
said that now only 45 million will be available by October due to
production delays—leaving up to 200 million Americans not immunized.

Next month, Australia may be the first nation to begin vaccinating its
citizens, making 2 million doses available. Already, "Australia's
death toll from the virus reached 128, and there are 460 people in
Australian hospitals with H1N1, 94 of them in intensive
care" (Bloomberg).

But the quantity available is still far less than that which was
originally expected, and health officials agree that while vaccination
is a start, it is not a surefire solution. The virus could morph and
render all produced vaccines unusable, making social distancing (as
with 1918) the best option.

In his book The Life of Reason, famed historian George Santayana once
said, "Those who cannot remember the past are condemned to repeat it."

Judging from history, humanity is setting itself up to confront
another "Mother of All Pandemics." Will we learn from the past, and
glean from the experiences that those, such as the father standing in
line with his children in 1918, had? Or will we choose to ignore the
clear pattern of history that always repeats itself?

To learn more about this topic, read our series on the Four Horsemen
of the book of Revelation.

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